South Africa has recorded 18 confirmed mpox cases and one probable case as of Thursday, 17 September 2026, prompting the Department of Health to urge residents to watch for symptoms and seek medical care. Fifteen cases have been reported in the Western Cape, three in Gauteng and one in KwaZulu Natal, with most infections concentrated in Cape Town. The department issued its warning on Friday, 18 September, after 13 of the 19 cases were recorded within five weeks, raising concern about recent local transmission.