Meet Professor Mahlatse Kgokolo: Pioneering Dermatology Research in South Africa
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Championing Dermatology with Dedication and Expertise
In the world of dermatology, few individuals have made as profound an impact as Professor Mahlatse Kgokolo, a trailblazer in the field of skin research, patient care, and academic leadership. As the Head of Dermatology at Steve Biko Academic Hospital, Prof Kgokolo has dedicated her career to transforming dermatology in South Africa and globally. She particularly focuses on the treatment of rare genetic skin disorders like xeroderma pigmentosum (XP).
Her work is rooted in both scientific rigor and a compassionate approach, making her one of the foremost experts in dermatogenetics. This is the study of genetic disorders affecting the skin, such as XP, which is characterized by extreme sensitivity to ultraviolet light and an elevated risk of skin cancer.
A Journey of Passion and Purpose
Prof Kgokolo’s journey into medicine was shaped by early inspiration from her hometown of Lebowakgomo, Limpopo. A local General Practitioner (GP) had a lasting influence on her career. She recalls the long waits at his clinic, but also the thoroughness and care he showed his patients, which sparked her passion for medicine.
“I always knew, and I was very clear with my mother, that I wanted to be a doctor,” says Prof Kgokolo. This drive, fueled by the example set by her local GP, led her to pursue a career in healthcare with a focus on skin disorders.
Her path to becoming a dermatologist was not easy. She initially started her career as a pharmacist before transitioning into medicine at MEDUNSA (now Sefako Makgatho Health Sciences University). Although she was initially drawn to obstetrics and gynaecology, her fascination with dermatology grew. She realized its unique blend of scientific research and hands-on patient care.
A Leader in Dermatology and Research
Prof Kgokolo is South Africa’s only dermatologist to hold three fellowships, a testament to her unwavering commitment to excellence. She serves as the President of the College of Dermatologists of South Africa and is a respected figure in the dermatology community, both locally and internationally.
Her research focuses primarily on xeroderma pigmentosum (XP), a rare and life-threatening condition. Under her leadership, significant advancements have been made in understanding the genetic mutations that contribute to XP. This is particularly true in South African populations.
“Before I began my PhD, publications indicated that the life expectancy of a South African patient with XP was just 13 years. I set out to change that reality,” says Prof Kgokolo. Her groundbreaking work has contributed to the development of new guidelines for managing XP, leading to patients living significantly longer and healthier lives.
Groundbreaking Research and Global Recognition
One of Prof Kgokolo’s most notable contributions has been in the area of genetic dermatology. Her research led to the identification of novel genetic mutations in a cohort of South African patients. These findings have helped to advance global understanding of dermatogenetics. Her work has earned her international recognition and significantly contributed to the global body of dermatological knowledge.
Her work has also influenced the development of personalized medicine, particularly in the treatment of rare genetic skin disorders. Prof Kgokolo’s efforts have highlighted the importance of including underrepresented populations in research. This ensures that treatments and interventions are tailored to the diverse needs of global communities.
Mentorship and Legacy
As a mentor, Prof Kgokolo is deeply invested in shaping the future of dermatology in South Africa. She plays an instrumental role in training medical students and registrars. Prof Kgokolo guides the next generation of dermatologists in their academic and clinical careers. Her ability to balance leadership in research with hands-on teaching ensures that her impact extends beyond her own career.
One of her proudest moments came when five of her registrars graduated with double distinctions. They achieved cum laude honors at both the Colleges of Medicine of South Africa and the University of Pretoria.
“I have opportunities to train and positively influence young medical students and registrars,” says Prof Kgokolo. Her commitment to mentorship ensures that her legacy will continue to shape the field for years to come.
New Frontiers in Dermatology
Looking ahead, Prof Kgokolo is spearheading three PhD projects in collaboration with the Department of Immunology. These projects focus on areas that promise to significantly advance the field of dermatology research. They aim to further strengthen South Africa’s contributions to dermatology, particularly in areas of genetic research and personalized treatment plans.
Her ongoing dedication to improving the quality of life for her patients continues to drive her research. She seeks to bridge gaps in the care of individuals with complex dermatological conditions.
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A Trailblazer for South Africa and Beyond
Professor Mahlatse Kgokolo’s work exemplifies the intersection of scientific excellence and compassionate patient care. As a leading researcher, educator, and advocate for those with rare genetic skin disorders, Prof Kgokolo’s career is a model of how innovative research can change lives.
Her contributions to dermatology not only elevate South Africa’s role in global medical research but also ensure that patients’ needs, particularly those from underrepresented communities, are placed at the heart of scientific advancement. Prof Kgokolo’s work continues to inspire future generations of doctors and researchers, fostering a brighter future for dermatology in South Africa and around the world.
